The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome [106169/ZZ14/Z]. This work was supported by funding from the Natural Sciences and Engineering Research Council (PGSD3) to DI. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. E.G. is supported by NMRC/OFIRG/0032/2017 and NRF-CRP17-2017-06 grants. The authors would like to thank Drs. B.L. Roth and J. Driscoll, the National Institute of Mental Health’s (NIMH) Psychoactive Drug Screening Program, for providing GPCR functional profiles. Natural Sciences and Engineering Research Council (RGPIN-2015-05939) to C.H.A.