Body composition measurement in young children using quantitative magnetic resonance: A comparison with air displacement plethysmography

Body composition measurement in young children using quantitative magnetic resonance: A comparison with air displacement plethysmography

Pediatric Obesity

10.1111/ijpo.12250

https://doi.org/10.1111/ijpo.12250

L.‐W. Chen, M.‐T. Tint, M. V. Fortier, I. M. Aris, L. P.‐C. Shek, K. H. Tan, V. S. Rajadurai, P. D. Gluckman, Y.‐S. Chong, K. M. Godfrey, M. S. Kramer, C. J. Henry, F. Yap, Y. S. Lee

12 October 2017

Chen, L.‐W., Tint, M.‐T., Fortier, M. V., Aris, I. M., Shek, L. P.‐C., Tan, K. H., Rajadurai, V. S., Gluckman, P. D., Chong, Y.‐S., Godfrey, K. M., Kramer, M. S., Henry, C. J., Yap, F., and Lee, Y. S. ( 2018) Body composition measurement in young children using quantitative magnetic resonance: a comparison with air displacement plethysmography. Pediatric Obesity, 13: 365– 373. doi: 10.1111/ijpo.12250.

Background: Quantitative magnetic resonance (QMR) has been increasingly used to measure human body composition, but its use and validation in children is limited. Objective: We compared body composition measurement by QMR and air displacement plethysmography (ADP) in preschool children from Singapore's multi‐ethnic Asian population (n = 152; mean ± SD age: 5.0 ± 0.1 years). Methods: Agreements between QMR‐based and ADP‐based fat mass and fat mass index (FMI) were assessed using intraclass correlation coefficient (ICC), reduced major axis regression and Bland–Altman plot analyses. Analyses were stratified for the child's sex. Results: Substantial agreement was observed between QMR‐based and ADP‐based fat mass (ICC: 0.85) and FMI (ICC: 0.82). Reduced major axis regression analysis suggested that QMR measurements were generally lower than ADP measurements. Bland–Altman analysis similarly revealed that QMR‐based fat mass were (mean difference [95% limits of agreement]) −0.5 (−2.1 to +1.1) kg lower than ADP‐based fat mass and QMR‐based FMI were −0.4 (−1.8 to +0.9) kg/m2 lower than ADP‐based FMI. Stratification by offspring sex revealed better agreement of QMR and ADP measurements in girls than in boys. Conclusions: QMR‐based fat mass and FMI showed substantial agreement with, but was generally lower than, ADP‐based measures in young Asian children.

This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, and Nestec. Study sponsors were not involved in the design of the study, statistical analysis and results interpretation. KMG is supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre and by the European Union's Seventh Framework Programme (FP7/2007-2013), projects EarlyNutrition and ODIN (Food-Based Solutions for Optimal Vitamin D Nutrition and Health through the Life Cycle) under grant agreements nos 289346 and 613977.

The author manuscript is available freely at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805128/

https://oar.a-star.edu.sg/communities-collections/articles/15908

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Singapore Institute for Clinical Sciences