Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study

Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study
Title:
Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study
Other Titles:
The American Journal of Clinical Nutrition
Publication Date:
27 March 2020
Citation:
Mya-Thway Tint, Suresh A Sadananthan, Shu-E Soh, Izzuddin M Aris, Navin Michael, Kok H Tan, Lynette P C Shek, Fabian Yap, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, S Sendhil Velan, Shiao-Yng Chan, Johan G Eriksson, Marielle V Fortier, Cuilin Zhang, Yung S Lee, Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother–offspring birth cohort study, The American Journal of Clinical Nutrition, , nqaa055, https://doi.org/10.1093/ajcn/nqaa055
Abstract:
Background: Gestational diabetes is associated with unfavorable body fat distribution in the offspring. However, less is known about the effects across the range of maternal gestational glycemia on offspring’s abdominal adiposity in infancy and early childhood. Objective: This study determined the association between gestational glycemia and offspring’s abdominal adiposity measured by magnetic resonance imaging (MRI) in the neonatal period and at preschool years. Design: Participants were mother-offspring pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective cohort study. Children who underwent MRI within 2weeks post-delivery (N=305) and/or at preschool age, 4.5 years (N=273), and whose mothers had a 2-hour 75g oral glucose tolerance test (OGTT) at 26-28 gestational weeks were included. Abdominal adiposity measured by adipose tissue compartment volumes; superficial (sSAT), deep subcutaneous (dSAT), and internal (IAT) abdominal adipose tissue were quantified from MRI images. Results: Adjusting for potential confounders including maternal pre-pregnancy BMI, each 1 mmol/L increase in maternal fasting glucose was associated with higher sSAT, differences in standard deviations scores (SD) (95%CI); 0.66 (0.45, 0.86), dSAT: 0.65 (0.44, 0.87) and IAT: 0.64 (0.42, 0.86) in neonates. Similarly, each 1 mmol/L increase in 2-hour OGTT glucose was associated with higher neonatal sSAT, 0.11 (0.03, 0.19) and dSAT, 0.09 (0.00, 0.17). These associations were stronger in female neonates but only persisted in girls between fasting glucose, and sSAT and dSAT at 4.5 years. Conclusions: A positive association between maternal glycemia and neonatal abdominal adiposity was observed across the whole range of maternal mid-gestation glucose concentrations. These findings may lend further support on efforts of optimizing maternal hyperglycemia during pregnancy. The study also provides a suggestive evidence on sex differences of the impact of maternal glycemia which merits further confirmation in other studies.
License type:
PublisherCopyrights
Funding Info:
This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore.
Description:
This is a pre-copyedited, author-produced version of an article accepted for publication in The American Journal of Clinical Nutrition following peer review. The version of record Mya-Thway Tint, Suresh A Sadananthan, Shu-E Soh, Izzuddin M Aris, Navin Michael, Kok H Tan, Lynette P C Shek, Fabian Yap, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, S Sendhil Velan, Shiao-Yng Chan, Johan G Eriksson, Marielle V Fortier, Cuilin Zhang, Yung S Lee, Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother–offspring birth cohort study, The American Journal of Clinical Nutrition, nqaa055, https://doi.org/10.1093/ajcn/nqaa055, is available online at: https://doi.org/10.1093/ajcn/nqaa055.
ISSN:
0002-9165
1938-3207
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