Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life

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Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life
Title:
Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life
Journal Title:
BMC Pediatrics
Keywords:
Publication Date:
02 June 2017
Citation:
Loo EX, Goh A, Aris IBM, et al. Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life. BMC Pediatr. 2017;17(1):134. Published 2017 Jun 2. doi:10.1186/s12887-017-0890-0
Abstract:
Background The association between early weight gain and later allergic outcomes has not been well studied. We examined the relation between weight gain and the subsequent development of allergic outcomes in the first 36 months of life in a Singapore birth cohort. Methods In repeated visits in the first 15 months, we measured infant weight and administered questionnaires ascertaining allergic outcomes. At ages 18 and 36 months, we administered skin prick tests (SPTs) to inhalant and food allergens. Results At 18 months, 13.5% had a positive SPT, 3.5% had wheeze and a positive SPT, 3.9% had rhinitis and a positive SPT, and 6.1% had eczema and a positive SPT. Higher weight gain from 6 to 9 months, 9 to 12 months and 12 to 15 months were independently associated with a reduced risk of developing a positive SPT at 18 months (p-trend ≤0.03). At 36 months, 23.5% had a positive SPT, 11.9% had wheeze and a positive SPT, 12.2% rhinitis and a positive SPT, and 11.5% eczema and a positive SPT. Higher weight gain from 12 to 15 months was associated with a reduced risk of developing a positive SPT at 36 months (p-trend
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. This work is also supported by the National Medical Research Council, NMRC/CSA/022/2010 and NRF370062-HUJ-NUS (Project 10). Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. KMG is funded by the NIHR through the NIHR Southampton Biomedical Research Centre. The funders are not involved in the design and conduct of the study, data analysis and preparation of manuscript.
Description:
ISSN:
1471-2431
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