Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles

Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
Title:
Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
Other Titles:
Antibody Therapeutics
Publication Date:
18 April 2020
Citation:
Wei-Li Ling, Wai-Heng Lua, Samuel Ken-En Gan, Sagacity in Antibody humanization for therapeutics, diagnostics and research purposes: Considerations of antibody elements and their roles., Antibody Therapeutics, , tbaa005, https://doi.org/10.1093/abt/tbaa005
Abstract:
Mutations underpin the processes in life, be it beneficial or detrimental. While mutations are assumed to be random in the bereft of selection pressures, the genetic code has underlying computable probabilities in amino acid phenotypic changes. With a wide range of implications including drug resistance, understanding amino acid changes is important. In this study, we calculated the probabilities of substitutions mutations in the genetic code leading to the 20 amino acids and stop codons. Our calculations reveal an enigmatic in-built self-preserving organization of the genetic code that averts disruptive changes at the physicochemical properties level. These changes include changes to start, aromatic, negative charged amino acids and stop codons. Our findings thus reveal a statistical mechanism governing the relationship between amino acids and the universal genetic code.
License type:
http://creativecommons.org/licenses/by-nc/4.0/
Funding Info:
This work was supported by A∗STAR core funds.
Description:
ISSN:
2516-4236
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