Multiscale modelling and simulation of viruses

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Multiscale modelling and simulation of viruses
Multiscale modelling and simulation of viruses
Other Titles:
Current Opinion in Structural Biology
Publication Date:
25 January 2020
Jan K Marzinek, Roland G Huber, Peter J Bond, Multiscale modelling and simulation of viruses, Current Opinion in Structural Biology, Volume 61, 2020, Pages 146-152, ISSN 0959-440X,
In recent years, advances in structural biology, integrative modelling, and simulation approaches have allowed us to gain unprecedented insights into viral structure and dynamics. In this article we survey recent studies utilizing this wealth of structural information to build computational models of partial or complete viruses and to elucidate mechanisms of viral function. Additionally, the close interplay of viral pathogens with host factors - such as cellular and intracellular membranes, receptors, antibodies, and other host proteins - makes accurate models of viral interactions and dynamics essential. As viruses continue to pose severe challenges in prevention and treatment, enhancing our mechanistic understanding of viral infection is vital to enable the development of novel therapeutic strategies.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research is supported by core funding from: Bioinformatics Institute
Grant Reference no. :

This research / project is supported by the National Research Foundation, Singapore - -
Grant Reference no. : NRF2017NRF-CRP001-027
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