Lee WC, Russell B and Rénia L (2019) Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm. Front. Immunol. 10:1444. doi: 10.3389/fimmu.2019.01444
Abstract:
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the infected erythrocytes. Cytoadherence plays a central role in the parasite's immune-escape mechanism, at the same time contributing to the pathogenesis of severe falciparum malaria. In this review, we discuss the cytoadhesive interactions between P. falciparum infected erythrocytes and various host cell types, and how these events are linked to malaria pathogenesis. We also highlight the limitations faced by studies attempting to correlate diversity in parasite ligands and host receptors with the development of severe malaria.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
WL was supported by funding from SIgN and Open FundYoung Individual Research Grant (NMRC/OFYIRG/0070/2018) by the National Medical Research Council, Ministry of Health, Singapore. LR was supported by core funding to SIgN from A∗STAR and the Horizontal Programme on Infectious Diseases under A∗STAR. BR was supported by University of Otago startup grant.