ZIF nano-dagger coated gauze for antibiotic-free wound dressing

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ZIF nano-dagger coated gauze for antibiotic-free wound dressing
ZIF nano-dagger coated gauze for antibiotic-free wound dressing
Journal Title:
Chemical Communications
Publication Date:
11 December 2018
Chem. Commun., 2019,55, 699-702
Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.
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Funding Info:
This work was supported by the Institute of Bioengineering and Nanotechnology and the NanoBio Lab (Biomedical Research Council, Agency for Science, Technology and Research, Singapore), and the National Research Foundation (Prime Minister’s Office, Singapore) under the Competitive Research Programme (NRF2017_CRP001_008).
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