This work was funded by Glaxo Wellcome Manufacturing PTE LTD and Agency for Science, Technology and Research (A*STAR) (GIS/15-IAF100) and supported by the Lung Cancer Consortium Singapore (LCCS) and the National Medical Research Council (Singapore) through the Translational and Clinical Research Program (NMRC/TCR/007-NCC/2013). LCCS is jointly supported by philanthropy (Singapore Millenium Foundation, etc.), institutional and industrial grants. W.Z is supported in part by the National Key R&D program of China grant 2018YFC0910400 and 2018YFC1406902. We thank Beijing Genomics Institute for providing the published sequencing data. We thank Chin Thing Jo Ong, Yen Ling Lee, Ivan Ming Lai Chua and Wendy Wei Jia Soon for next generation sequencing work, GIS Research Pipeline Development team for support on analysis pipelines, Yasuji Matsuoka for administrative support. We thank Dr Lee May Ann of the Experimental Therapeutics Centre, A*STAR, Singapore for providing the ETCC016 (RRID: CVCL_Y086) cell line. We thank
Prof Cun Yupeng for helpful discussions.