Spinal cord organoids add an extra dimension to traditional motor neuron cultures

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Spinal cord organoids add an extra dimension to traditional motor neuron cultures
Title:
Spinal cord organoids add an extra dimension to traditional motor neuron cultures
Journal Title:
Neural Regeneration Research
Keywords:
Publication Date:
09 May 2019
Citation:
Winanto, Khong ZJ, Hor JH, Ng SY. Spinal cord organoids add an extra dimension to traditional motor neuron cultures. Neural Regen Res [serial online] 2019 [cited 2020 Apr 30];14:1515-6. Available from: http://www.nrronline.org/text.asp?2019/14/9/1515/255966
Abstract:
Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).
License type:
http://creativecommons.org/licenses/by-nc-sa/4.0/
Funding Info:
Description:
ISSN:
1673-5374
1876-7958
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