Science 12 Oct 2018: Vol. 362, Issue 6411, pp. 185-189 DOI: 10.1126/science.aat0474
Abstract:
Cross-talk between the nervous and immune systems has been well described in the context of adult physiology and disease. Recent advances in our understanding of immune cell ontogeny have revealed a notable interplay between neurons and microglia during the prenatal and postnatal emergence of functional circuits. This Review focuses on the brain, where the early symbiotic relationship between microglia and neuronal cells critically regulates wiring, contributes to sex-specific differences in neural circuits, and relays crucial information from the periphery, including signals derived from the microbiota. These observations underscore the importance of studying neurodevelopment as part of a broader framework that considers nervous system interactions with microglia in a whole-body context.
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Funding Info:
S.G.’s laboratory is supported by INSERM, CNRS, Investissements d’Avenir (ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-0001-02 PSL* Research University) and the ERC Consolidator NImO 616080. S.G. is part of the École des Neurosciences de Paris Île-de-France network. F.G. is an EMBO YIP awardee and is supported by
Singapore Immunology Network (SIgN) core funding, as well as Singapore National Research Foundation Senior Investigatorship (NRFI) NRF2016NRF-NRFI001-02.
Description:
The full paper is available for download at the publisher's URL: https://doi.org/10.1126/science.aat0474