Rate of establishing the gut microbiota in infancy has consequences for future health

Rate of establishing the gut microbiota in infancy has consequences for future health
Rate of establishing the gut microbiota in infancy has consequences for future health
Other Titles:
Gut Microbes
Publication Date:
20 August 2015
Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Brück WM, Berger B, Brüssow H, Karnani N, Lee YS, Yap F, Chong YS, Godfrey KM, Holbrook JD. "Rate of establishing the gut microbiota in infancy has consequences for future health". Gut Microbes. 2015;6(5):321-5. doi: 10.1080/19490976.2015.1078051.
The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occur in the species prevalent in our guts. Although the sequential progression of these species is remarkably consistent across individuals and geographies, there is inter-individual variation in the rate of progression. Our study and others suggest that the rate is influenced by environmental factors, and influences our future health. In this article, we review our recent contribution to cataloging the developing infant gut microbiota alongside other important recent studies. We suggest testable hypotheses that arise from this synthesis.
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Funding Info:
This work was supported by the Translational Clinical Research Flagship Program on Developmental Pathways to Metabolic Disease funded by the National Research Foundation and administered by the National Medical Research Council, Singapore (NMRC/TCR/004-NUS/2008). Additional funding was provided by the Agency for Science and Technology Research (A*STAR) and Nestlé.
Addendum to: Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Bruck WM, Berger B, Brussow H, Lee YS, Yap F, Chong YS, et al. Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio 2015 Feb 3;6(1); pii: e02419–14; http://dx.doi. org/10.1128/mBio.02419–14
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