Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm

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Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm
Title:
Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm
Journal Title:
Clinical Epigenetics
Publication Date:
11 February 2019
Citation:
Wu Y, Lin X, Lim IY, Chen L, Teh AL, MacIsaac JL, Tan KH, Kobor MS, Chong YS, Gluckman PD, Karnani N. “Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm”. Clin Epigenetics. 2019 Feb 11;11(1):26. doi: 10.1186/s13148-018-0599-4.
Abstract:
BACKGROUND: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes. Thus, epigenome-wide association studies (EWAS), where DNAm sites are examined for associations with PTB, can help shed light on the biological mechanisms linking the two. RESULTS: In an Asian cohort of 1019 infants (68 preterm, 951 full term), we examined and compared the associations between PTB and genome-wide DNAm profiles using both cord tissue (n = 1019) and cord blood (n = 332) samples on Infinium HumanMethylation450 arrays. PTB was significantly associated (P 
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This work was supported by the Translational Clinical Research (TCR) Flagship Program on Developmental Pathways to Metabolic Disease funded by the National Research Foundation (NRF) and administered by the National Medical Research Council (NMRC), Singapore—NMRC/TCR/004-NUS/2008. Additional funding is provided by Strategic Positioning Fund (SPF) awarded by Agency for Science, Technology and Research (A*STAR), Singapore, available to NK. XL is supported by Duke-NUS block fund (R-913-200-127-263) and Ministry of Education, Singapore Academic Research grant Tier 2 (MOE2018-T2-1-046).
Description:
ISSN:
1868-7075
1868-7083
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