The authors thank members of the Teo laboratory for the critical reading of this manuscript. N.S.A. and B.S.J.L. are supported by the NUS Research Scholarship. T.E.S. and A.K.K.T. are supported by the NMRC OF-LCG/DYNAMO. A.K.K.T. is further supported by the Institute of Molecular and Cell Biology (IMCB), A*STAR, A*STAR JCO Career Development Award (CDA) 15302FG148, NMRC OFYIRG16may014, A*STAR ETPL Gap Funding ETPL/18-GAP005-R20H, Lee Foundation Grant SHTX/LFG/002/2018, Skin Innovation Grant SIG18011, FY2019 SingHealth Duke-NUS Surgery Academic Clinical Programme Research Support Programme Grant, Precision Medicine and Personalised Therapeutics Joint Research Grant 2019, and the Industry Alignment Fund – Industry Collaboration Project (IAF-ICP).