A new perspective of probe development for imaging pancreatic beta cell in vivo

A new perspective of probe development for imaging pancreatic beta cell in vivo
Title:
A new perspective of probe development for imaging pancreatic beta cell in vivo
Other Titles:
Seminars in Cell & Developmental Biology
Keywords:
Publication Date:
11 February 2020
Citation:
Claire Wen Ying Neo, Larissa Miasiro Ciaramicoli, Andreas Alvin Purnomo Soetedjo, Adrian Kee Keong Teo, Nam-Young Kang, A new perspective of probe development for imaging pancreatic beta cell in vivo, Seminars in Cell & Developmental Biology, 2020, ISSN 1084-9521, https://doi.org/10.1016/j.semcdb.2020.01.009.
Abstract:
Beta cells assume a fundamental role in maintaining blood glucose homeostasis through the secretion of insulin, which is contingent on both beta cell mass and function, in response to elevated blood glucose levels or secretagogues. For this reason, evaluating beta cell mass and function, as well as scrutinizing how they change over time in a diabetic state, are essential prerequisites in elucidating diabetes pathophysiology. Current clinical methods to measure human beta cell mass and/or function are largely lacking, indirect and sub-optimal, highlighting the continued need for noninvasive in vivo beta cell imaging technologies such as optical imaging techniques. While numerous probes have been developed and evaluated for their specificity to beta cells, most of them are more suited to visualize beta cell mass rather than function. In this review, we highlight the distinction between beta cell mass and function, and the importance of developing more probes to measure beta cell function. Additionally, we also explore various existing probes that can be employed to measure beta cell mass and function in vivo, as well as the caveats in probe development for in vivo beta cell imaging.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
K.N.Y is supported by the Korea Health Technology R&D Project though KHIDI (HI19C-0316-010019). C.W.Y.N. is supported by the NUS Research Scholarship. A.K.K.T. is supported by the Institute of Molecular and Cell Biology (IMCB), A*STAR, A*STAR JCO Career Development Award (CDA)15302FG148, NMRC OFYIRG16may014, A*STAR ETPL Gap Funding ETPL/18-GAP005-R20H, NMRC OF-LCG/DYNAMO, Lee Foundation Grant SHTX/LFG/002/2018, Skin Innovation Grant SIG18011, FY2019 SingHealth Duke-NUS Surgery Academic Clinical Programme Research Support Programme Grant, Precision Medicine and Personalised Therapeutics Joint Research Grant 2019, Industry Alignment Fund – Industry Collaboration Project (IAFICP), and the 2nd A*STAR-AMED Joint Grant Call 192B9002.
Description:
ISSN:
1084-9521
1096-3634
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