N.H.J.N. is supported by the National Medical Research Council (NMRC) Open Fund-Young Individual Research Grant (OF-YIRG) OFYIRG18May. W.X.T. is supported by the NUS Research Scholarship. Y.X.K. and A.K.K.T. are supported by the Lee Foundation Grant SHTX/LFG/002/2018, FY2019 SingHealth Duke-NUS Surgery Academic Clinical Programme Research Support Programme Grant and SingHealth Duke-NUS Transplant Centre – Multi-Visceral Transplant Fund Award. A.K.K.T. is further supported by the Institute of Molecular and Cell Biology (IMCB), A*STAR, the JCO Career Development Award (CDA) 15302FG148, NMRC OF-YIRG OFYIRG16may014, MRC Research Grant, A*STAR ETPL Gap Funding ETPL/18-GAP005-R20H, Skin Innovation Grant SIG18011, NMRC OF-LCG/DYNAMO, Precision Medicine and Personalised Therapeutics Joint Research Grant 2019 and Industry Alignment Fund-Industry Collaboration Project (IAF-ICP).