Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia

Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
Title:
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
Other Titles:
Stem Cell Reports
Publication Date:
16 April 2020
Citation:
Tan et al., Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia, Stem Cell Reports (2020), https://doi.org/10.1016/j.stemcr.2020.03.013
Abstract:
Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This study was funded by National Research Foundation Singapore, NRF-NRFF2015-05.
Description:
ISSN:
2213-6711
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