Chandrasekharan, P., Yang, C.‐T., Nasrallah, F. A., Tay, H. C., Chuang, K.‐H., and Robins, E. G. ( 2015), Pharmacokinetics of Gd(DO3A‐Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model. Contrast Media Mol. Imaging, 10, 237– 244. doi: 10.1002/cmmi.1634.
Abstract:
Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium-based magnetic resonance imaging (MRI) contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data were fitted using a twocompartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(α), of 1.3 min, an elimination half-life, t1/2(β), of 24.9 min and a large volume of distribution, VD, of 0.49 L/kg indicative of the agent being able to rapidly distribute into tissues and organs. Contrast-enhanced magnetic resonance angiography (CE-MRA) in an orthotopic U87MG glioma mouse model demonstrated considerable enhancement of both the tumor and surrounding vasculature after intravenous administration of Gd(DO3A-Lys). Applying dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the glioma of different sizes further showed distinct uptake characteristics and patterns of enhancement, which suggests the potential for differentiating changes at different stages of tumor growth. Our results indicate that Gd(DO3A-Lys) could be a promising candidate for glioma MR imaging.
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Funding Info:
This work was supported by COT Grant ETPL/10-S10COT-006 of A*STAR (Agency for Science, Technology and Research); Singapore Bioimaging Consortium Intramural Funding of the Biomedical Research Council, Singapore.
Description:
This is an open access article, the full paper can be downloaded from the publisher's URL here: https://doi.org/10.1002/cmmi.1634