Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate

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Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate
Title:
Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate
Journal Title:
Carbon Letters
Keywords:
Publication Date:
31 July 2018
Citation:
Shen, S.-C.; Ng, W. K.; Letchmanan, K.; Lim, R. T. Y.; Tan, R. B. H., Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. Carbon Letters 2018, 27 (1), 18-25.
Abstract:
In this study, graphene oxide(GO) was used as drug carriers to amorphize poorly watersoluble drugs via a co-spray drying process. Two poorly water-soluble drugs, fenofibrate and ibuprofen, were investigated. It was found that the drug molecules could be in the graphene nanosheets in amorphous or nano crystalline forms and thus have a significantly enhanced dissolution rate compared with the counterpart crystalline form. In addition, the dissolution of the amorphous drug enwrapped with the graphene oxide was higher than that of the amorphous drug in activated carbon (AC) even though the AC possessed a larger specific surface area than that of the graphene oxide. The amorphous formulations also remained stable under accelerated storage conditions ( and 75% relative humidity) for a study period of 14 months. Therefore, graphene oxide could be a potential drug carrier and amorphization agent for poorly water-soluble drugs to enhance their bioavailability.
License type:
http://creativecommons.org/licenses/by-nc/4.0/
Funding Info:
This work was funded by the Institute of Chemical and Engineering Sciences (ICES) under the Agency for Science, Technology and Research (A*STAR).
Description:
ISSN:
1976-4251
2233-4998
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