Cellular stress drives pancreatic plasticity

Page view(s)
12
Checked on Feb 03, 2024
Cellular stress drives pancreatic plasticity
Title:
Cellular stress drives pancreatic plasticity
Journal Title:
Science Translational Medicine
Keywords:
Publication Date:
04 February 2015
Citation:
Science Translational Medicine 04 Feb 2015: Vol. 7, Issue 273, pp. 273ps2
Abstract:
Controversy has long surrounded research on pancreatic beta cell regeneration. Some groups have used nonphysiological experimental methodologies to build support for the existence of pancreatic progenitor cells within the adult pancreas that constantly replenish the beta cell pool; others argue strongly against this mode of regeneration. Recent research has reinvigorated enthusiasm for the harnessing of pancreatic plasticity for therapeutic application—for example, the transdifferentiation of human pancreatic exocrine cells into insulin-secreting beta-like cells in vitro; the conversion of mouse pancreatic acinar cells to beta-like cells in vivo via cytokine treatment; and the potential redifferentiation of dedifferentiated mouse beta cells in vivo. Here, we highlight key findings in this provocative field and provide a perspective on possible exploitation of human pancreatic plasticity for therapeutic beta cell regeneration.
License type:
PublisherCopyrights
Funding Info:
Description:
Full paper is available for download at: https://doi.org/10.1126/scitranslmed.3010577
ISSN:
1946-6234
1946-6242
Files uploaded:
File Size Format Action
There are no attached files.