An in vitro investigation of photodynamic efficacy of FosPeg® on human colon cancer cells

An in vitro investigation of photodynamic efficacy of FosPeg® on human colon cancer cells
Title:
An in vitro investigation of photodynamic efficacy of FosPeg® on human colon cancer cells
Other Titles:
Journal of Innovative Optical Health Sciences
DOI:
10.1142/S1793545815500273
Keywords:
Publication Date:
25 January 2015
Citation:
Journal of Innovative Optical Health Sciences Vol. 08, No. 05, 1550027 (2015)
Abstract:
Photodynamic therapy (PDT) is a novel therapeutic approach for combating various cancers. PDT involves the administration of a photosensitizer which generates singlet oxygen after light activation. FosPegⓇ is the liposomal formulation of mTHPC. In this in vitro study, the photodynamic efficacy of FosPegⓇ on a human colon cancer cell line (HT29) was investigated via studying the cellular uptake of FosPegⓇ, FosPegⓇ PDT mediated photocytotoxicity and the cell death mechanism were triggered. FosPegⓇ PDT demonstrated its antitumor effect in a drug and light dose-dependent manner in HT-29 cells. Lethal dose (LD50) was achieved with 0.4 μg/mL of drug and 3 J/cm-2 of light dose. FosPegⓇ PDT triggered apoptotic cell death via activating caspase cascade and regulating cell cycle progression. In conclusion, FosPegⓇ-PDT is an effective measure to combat human colon cancer cells.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
Description:
ISSN:
1793-5458
1793-7205
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