Role of FcαR EC2 region in extracellular membrane localization

Role of FcαR EC2 region in extracellular membrane localization
Title:
Role of FcαR EC2 region in extracellular membrane localization
Other Titles:
Cell Cycle
Keywords:
Publication Date:
05 April 2018
Citation:
Ser-Xian Phua, Wai-Heng Lua & Samuel Ken-En Gan (2018): Role of FcαR EC2 region in extracellular membrane localization, Cell Cycle, DOI: 10.1080/15384101.2018.1444236
Abstract:
The FcaR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1–2]. FcaR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic tail region [3]. Previously, we reported that the EC1 region plays an essential role for extracellular membrane localization of the receptor [4], where the absence of EC1 would prevent the variants from localizing to the cell surface, even with a full signal peptide. In the case of FcaR Variant 4 (lacking the S2 region only), there was some “leakiness” to membrane surface localization.
License type:
PublisherCopyrights
Funding Info:
This work was supported by the JCO1334i00050 grant from Joint Council Office, Agency for Science, Technology, and Research (A STAR) in Singapore.
Description:
ISSN:
1538-4101
1551-4005
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