Rclick: a web server for comparison of RNA 3D structures

Rclick: a web server for comparison of RNA 3D structures
Title:
Rclick: a web server for comparison of RNA 3D structures
Other Titles:
Bioinformatics
Keywords:
Publication Date:
12 November 2014
Citation:
Minh N. Nguyen, Chandra Verma; Rclick: a web server for comparison of RNA 3D structures, Bioinformatics, Volume 31, Issue 6, 15 March 2015, Pages 966–968, https://doi.org/10.1093/bioinformatics/btu752
Abstract:
RNA molecules play important roles in key biological processes in the cell and are becoming attractive for developing therapeutic applications. Since the function of RNA depends on its structure and dynamics, comparing and classifying the RNA 3D structures is of crucial importance to molecular biology. In this study, we have developed Rclick, a web server that is capable of superimposing RNA 3D structures by using clique matching and 3D least-squares fitting. Our server Rclick has been benchmarked and compared with other popular servers and methods for RNA structural alignments. In most cases, Rclick alignments were better in terms of structure overlap. Our server also recognizes conformational changes between structures. For this purpose, the server produces complementary alignments to maximize the extent of detectable similarity. Various examples showcase the utility of our web server for comparison of RNA, RNA-protein complexes and RNA-ligand structures.
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PublisherCopyrights
Funding Info:
Description:
Full paper can be downloaded from the Publisher's URL provided.
ISSN:
1367-4803
1460-2059
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