Adaptation of Pandemic H2N2 Influenza A Viruses in Humans

Adaptation of Pandemic H2N2 Influenza A Viruses in Humans
Adaptation of Pandemic H2N2 Influenza A Viruses in Humans
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Journal of Virology
Publication Date:
10 December 2014
Joseph U, Linster M, Suzuki Y, Krauss S, Halpin RA, Vijaykrishna D, Fabrizio T, Bestebroer TM, Maurer-Stroh S, Webby RJ, Wentworth DE, Fouchier RAM, Bahl J, Smith GJD, members of the CEIRS H2N2 Working Group. 2015. Adaptation of pandemic H2N2 influenza A viruses in humans. J Virol 89:2442–2447. doi:10.1128/JVI.02590-14.
The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.
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Funding Info:
This study was supported by contracts HHSN266200700010C, HHSN272201400008C, HSN266200700005C, HHSN272200900007C, and HHSN272201400006C from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Department of Health and Human Services, United States, and by the Duke-NUS Signature Research Program funded by the Agency of Science, Technology and Research, Singapore, and the Ministry of Health, Singapore.
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