The contrasting phylodynamics of human influenza B viruses

The contrasting phylodynamics of human influenza B viruses
Title:
The contrasting phylodynamics of human influenza B viruses
Other Titles:
eLife
Keywords:
Publication Date:
16 January 2015
Citation:
eLife 2015;4:e05055 DOI: 10.7554/eLife.05055
Abstract:
A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
Description:
ISSN:
2050-084X
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