Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015

Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015
Title:
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015
Other Titles:
Antiviral Research
DOI:
10.1016/j.antiviral.2016.06.001
Keywords:
Publication Date:
03 June 2016
Citation:
Aeron C. Hurt, Terry G. Besselaar, Rod S. Daniels, Burcu Ermetal, Alicia Fry, Larisa Gubareva, Weijuan Huang, Angie Lackenby, Raphael T.C. Lee, Janice Lo, Sebastian Maurer-Stroh, Ha T. Nguyen, Dmitriy Pereyaslov, Helena Rebelo-de-Andrade, Marilda M. Siqueira, Emi Takashita, Masato Tashiro, Danielle Tilmanis, Dayan Wang, Wenqing Zhang, Adam Meijer, Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015, Antiviral Research, Volume 132, 2016, Pages 178-185, ISSN 0166-3542, https://doi.org/10.1016/j.antiviral.2016.06.001.
Abstract:
The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
The London WHO CC is funded by the British Medical Research Council through programme U117512723. The Melbourne WHO CC is supported by the Australian Government, Department of Health. The Tokyo WHO CC is supported by Grants-in-Aid for Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour andWelfare, Japan and by JSPS KAKENHI Grant number 26460816. RTCL and SMS are supported by a joint A*STAR-NHMRC grant (#12/1/06/24/5793).
Description:
ISSN:
0166-3542
1872-9096
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