Dang, T. T.; Seayad, A. M., Efficient [Cu(NHC)]-catalyzed multicomponent synthesis of pyrroles. Chemistry – An Asian Journal 2017, 12 (17), 2383-2387.
Abstract:
Efficient [Cu(NHC)]‐catalyzed syntheses of pyrroles via two and three‐component coupling methods are described. Various 1,2‐, 1,2,3‐, 1,2,3,5‐ and fully substituted pyrroles were readily accessible through a suitable choice of ketone, primary amine and diol in a three‐component reaction. The N‐unsubstituted pyrrole formation is also feasible through a two‐component reaction involving a β‐amino alcohol and a ketone.
License type:
PublisherCopyrights
Funding Info:
This work was funded by GSK-EDB Singapore Partnership for Green and Sustainable Manufacturing and the Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore.
Description:
This is the peer reviewed version of the following article: Dang, T. T.; Seayad, A. M., Efficient [Cu(NHC)]-catalyzed multicomponent synthesis of pyrroles. Chemistry – An Asian Journal 2017, 12 (17), 2383-2387, which has been published in final form at https://doi.org/10.1002/asia.201701045. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.