Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles

Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles

Journal of the Mechanical Behavior of Biomedical Materials

10.1016/j.jmbbm.2017.05.003

https://doi.org/10.1016/j.jmbbm.2017.05.003

Reginald B. H. Tan, Kumaran Letchmanan, Shou-Cang Shen, Wai Kiong Ng, Poddar Kingshuk, Zhilong Shi, Wilson Wang

02 May 2017

Letchmanan, K.; Shen, S. C.; Ng, W. K.; Kingshuk, P.; Shi, Z. L.; Wang, W.; Tan, R. B. H., Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles. Journal of the Mechanical Behavior of Biomedical Materials 2017, 72, 163-170.

The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15 wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging. In addition, the MSN-functionalized bone cements are able to increase the drug release of gentamicin (GTMC) significantly as compared with commercially available antibiotic-loaded bone cements. It can be attributed to the loaded nano-sized MSNs with uniform pore channels which build up an effective nano-network path enable the diffusion and extended release of GTMC. The combination of excellent mechanical properties and sustainable drug delivery efficiency demonstrates the potential applicability of MSN-functionalized PMMA bone cements for orthopedic surgery to prevent post-surgery infection.

http://creativecommons.org/licenses/by-nc-nd/4.0/

This work was generously supported by Biomedical Engineering Programme (BEP) 2014 Grant (ICES/14-422A02), the Institute of Chemical Engineering and Sciences, and the Agency of Science Technology and Research (A*STAR), Singapore.

https://oar.a-star.edu.sg/communities-collections/articles/13960

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Institute of Chemical and Engineering Sciences