Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent

Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent
Title:
Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent
Other Titles:
International Journal of Peptide Research and Therapeutics
Publication Date:
22 January 2018
Citation:
Teo, S.W., Yong, Y.E., Ng, S.M.S. et al. Int J Pept Res Ther (2018). https://doi.org/10.1007/s10989-018-9678-9
Abstract:
Pseudomonas aeruginosa is a Gram-negative pathogen responsible for a wide spectrum of infections including skin-related infections such as ecthyma gangrenosum, folliculitis, surgical site and burn wound infections. The global emergence of drug-resistant strains has become a clinical concern and new antibacterial agents are urgently needed. Antimicrobial peptides, with their membrane-disrupting mode of action, are deemed potential candidates. Herein, we screened 62 published short peptides, up to 11 residues in length, with reported antibacterial properties, against a multidrug-resistant strain of P. aeruginosa. Of the 3 most potent peptides, the shortest one was selected for further studies involving a panel of clinical P. aeruginosa strains, a bactericidal/static determination assay and a time-kill assay to gauge its potential for further development as a topical antibacterial drug candidate.
License type:
PublisherCopyrights
Funding Info:
Agency for Science, Technology and Research Biomedical Research Council
Description:
ISSN:
1573-3904
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