Cyclostomes Lack Clustered Protocadherins

Cyclostomes Lack Clustered Protocadherins
Title:
Cyclostomes Lack Clustered Protocadherins
Other Titles:
Molecular Biology and Evolution
Keywords:
Publication Date:
05 November 2015
Citation:
Molecular Biology and Evolution, Volume 33, Issue 2, 1 February 2016, Pages 311–315, https://doi.org/10.1093/molbev/msv252
Abstract:
The brain, comprising billions of neurons and intricate neural networks, is arguably the most complex organ in vertebrates. The diversity of individual neurons is fundamental to the neuronal network complexity and the overall function of the vertebrate brain. In jawed vertebrates, clustered protocadherins provide the molecular basis for this neuronal diversity, through stochastic and combinatorial expression of their various isoforms in individual neurons. Based on analyses of transcriptomes from the Japanese lamprey brain and sea lamprey embryos, genome assemblies of the two lampreys, and brain expressed sequence tags of the inshore hagfish, we show that extant jawless vertebrates (cyclostomes) lack the clustered protocadherins. Our findings indicate that the clustered protocadherins originated from a nonclustered protocadherin in the jawed vertebrate ancestor, after the two rounds of whole-genome duplication. In the absence of clustered protocadherins, cyclostomes might have evolved novel molecules or mechanisms for generating neuronal diversity which remains to be discovered.
License type:
PublisherCopyrights
Funding Info:
Description:
Full paper can be downloaded from the Publisher's URL provided.
ISSN:
0737-4038
1537-1719
Files uploaded:
File Size Format Action
There are no attached files.