Goh, W. Y. L.; Chai, C. L. L.; Chen, A. Q., Synthesis and biological studies of a triazole analogue of resorcylic acid lactone LL-Z1640-2. European Journal of Organic Chemistry 2014, 2014, (32), p 7239-7244..
Abstract:
A highly convergent and concise synthesis of a triazole analogue of resorcylic acid lactone natural product LL-Z1640-2 has been achieved from easily accessible starting materials in six linear steps in 18 % overall yield. Biological evaluation confirmed the enone system of the natural product is crucial for its activity. The triazole analogue showed good activity (IC50 7.2 μM) against MNK2 kinase, which is an emerging target for cancer chemotherapy.
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Funding Info:
This study was supported by Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR).
Description:
This is the peer reviewed version of the following article: Goh, W. Y. L.; Chai, C. L. L.; Chen, A. Q., Synthesis and biological studies of a triazole analogue of resorcylic acid lactone LL-Z1640-2. European Journal of Organic Chemistry 2014, 2014, (32), p 7239–7244, which has been published in final form at https://dx.doi.org/10.1002/ejoc.201403010. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.