The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer

Page view(s)
30
Checked on Sep 20, 2024
The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer
Title:
The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer
Journal Title:
OncoTargets and Therapy
Keywords:
Publication Date:
13 July 2015
Citation:
Abstract:
Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0.68 (95% confidence interval =0.56–0.83; P
License type:
http://creativecommons.org/licenses/by-nc/4.0/
Funding Info:
Description:
ISSN:
1178-6930
Files uploaded: