Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

Page view(s)
2
Checked on May 25, 2022
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems
Title:
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems
Other Titles:
Trends in Immunology
Keywords:
Publication Date:
02 October 2015
Citation:
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems Waisman, Ari et al. Trends in Immunology , Volume 36 , Issue 10 , 625 - 636
Abstract:
Microglia are brain macrophages that emerge from early erythro-myeloid pre-cursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained throughout lifespan. The mechanisms through which these embryonic-derived cells contribute to microglia homoeostasis at steady state and upon inflammation are still not entirely clear. Here we review recent studies that provided insight into the contribution of embryonically-derived microglia and of adult ‘microglia-like’ cells derived from monocytes during inflammation. We examine different microglia depletion models, and discuss the origin of their rapid repopulation after depletion and outline important areas of future research.
License type:
PublisherCopyrights
Funding Info:
Description:
ISSN:
1471-4906
1471-4981
Files uploaded:

Files uploaded: