Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

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Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore
Title:
Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore
Journal Title:
Journal of Virology
Keywords:
Publication Date:
11 February 2009
Citation:
Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore Mark J. Schreiber, Edward C. Holmes, Swee Hoe Ong, Harold S. H. Soh, Wei Liu, Lukas Tanner, Pauline P. K. Aw, Hwee Cheng Tan, Lee Ching Ng, Yee Sin Leo, Jenny G. H. Low, Adrian Ong, Eng Eong Ooi, Subhash G. Vasudevan, and Martin L. Hibberd J. Virol. May 1, 2009 83:9 4163-4173; Accepted manuscript posted online 11 February 2009, doi:10.1128/JVI.02445-08
Abstract:
Dengue is one of the most important emerging diseases of humans, with no preventative vaccines or antiviral cures available at present. Although one-third of the world's population live at risk of infection, little is known about the pattern and dynamics of dengue virus (DENV) within outbreak situations. By exploiting genomic data from an intensively studied major outbreak, we are able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial resolution. Two DENV serotypes (DENV-1 and DENV-3), and multiple component genotypes, spread concurrently and with similar epidemiological and evolutionary profiles during the initial outbreak phase of a major dengue epidemic that took place in Singapore during 2005. Although DENV-1 and DENV-3 differed in viremia and clinical outcome, there was no evidence for adaptive evolution before, during, or after the outbreak, indicating that ecological or immunological rather than virological factors were the key determinants of epidemic dynamics.
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Full paper can be downloaded from the Publisher's URL provided.
ISSN:
0022-538X
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