Chennamaneni, L. R.; William, A. D.; Johannes, C. W., Palladium-catalyzed decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides. Tetrahedron Letters 2015, 56 (11), 1293-1296.
Decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides is reported. Using a bimetallic system of Cu2O and Pd(PPh3)4, the scope of the reaction is demonstrated by the synthesis of 27 pyridine-containing biaryls in moderate to good yields.
Financial support provided by Institute of Chemical and Engineering Sciences, A*STAR (ICES/12-242A02).