Kwong, J. Y. D.; Richard, J. A., Synthesis of the 6-6-6 tricyclic skeleton of the anti-influenza A diterpene wickerol A. Tetrahedron Letters 2014, 55, (14), p 2183-2186.
Abstract:
A five-step synthesis of the 6-6-6 tricyclic skeleton of the diterpene wickerol A is described. The synthesis features a diastereoselective d-proline-mediated Robinson annulation and N-heterocyclic carbene-catalyzed Stetter reaction as key transformations to give the tricyclic carbon skeleton of this promising anti-influenza A natural product.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
Financial support for this work was provided by A*STAR, Singapore.