Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination

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Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination
Title:
Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination
Journal Title:
Chemical Communications
Keywords:
Publication Date:
25 September 2013
Citation:
Nguyen, T. M.; Duong, H. A.; Richard, J. A.; Johannes, C. W.; Fu, P. C.; Kwong, J. Y. D.; Lau, S. Y. E., Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination. Chemical Communications 2013, 49, (90), p 10602-10604.
Abstract:
Cascade fluorofunctionalisation of 2,3-unsubstituted indoles featuring the formation of C–C, C–F and C–O bonds via electrophilic fluorination using N-fluorobenzenesulfonimide is described. The use of an O-nucleophile tethered to the nitrogen of indoles enables the synthesis of polycyclic fluorinated indoline derivatives from simple precursors in 40–63% yields.
License type:
PublisherCopyrights
Funding Info:
Financial support for this work was provided by ICES, A*STAR, Singapore.
Description:
ISSN:
1359-7345
1364-548X
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