An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA).

An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA).
Title:
An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA).
Other Titles:
Antibiotics
DOI:
10.3390/antibiotics4040424
Publication Date:
09 October 2015
Citation:
Lau, Q.Y.; Tan, Y.Y.F.; Goh, V.C.Y.; Lee, D.J.Q.; Ng, F.M.; Ong, E.H.Q.; Hill, J.; Chia, C.S.B. An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA). Antibiotics 2015, 4, 424-434
Abstract:
The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has become endemic in hospitals worldwide. Drug repurposing, the finding of new therapeutic indications for approved drugs, is deemed a plausible solution to accelerate drug discovery and development in this area. Towards this end, we screened 1163 drugs approved by the Food and Drug Administration (FDA) for bioactivities against MRSA in a 10 μM single-point assay. After excluding known antibiotics and antiseptics, six compounds were identified and their MICs were determined against a panel of clinical MRSA strains. A toxicity assay using human keratinocytes was also conducted to gauge their potential for repurposing as topical agents for treating MRSA skin infections.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
A*STAR BMRC
Description:
Open-access article available at http://www.mdpi.com/journal/antibiotics
ISSN:
2079-6382
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