Ning Xue, Tao Sun, Wei Mong Tsang, Ignacio Delgado-Martinez, Sang-Hoon Lee, Swathi Sheshadri, Zhuolin Xiang, Srinivas Merugu, Yuandong Gu, Shih-Cheng Yen, Nitish V. Thakor, Polymeric C-shaped cuff electrode for recording of peripheral nerve signal, Sensors and Actuators B: Chemical, Volume 210, April 2015, Pages 640-648, ISSN 0925-4005, http://dx.doi.org/10.1016/j.snb.2015.01.006. (http://www.sciencedirect.com/science/article/pii/S0925400515000222)
tWe reported a polyimide-based C-shaped neural interface electrode to record peripheral nerve signalfrom the rat sciatic nerve. The neural interface electrode consisted of four recording probes protrudedfrom the C-shaped frame, and two reference electrode sites on the C-shaped frame. Thanks to the uniquebendable protruding structure of the recording probes, electrode sites were able to adapt to and main-tain close contact to the nerve without restricting nerve movement. Gold, gold–carbon nanotube (CNT)composite, and platinum were chosen as the electrode materials. The electrodes were characterized byelectrochemical impedance spectroscopy (EIS) analysis in phosphate buffer solution (PBS) (pH 7.4). Theresults showed that the gold-CNT electrode (area of 8500 m2) had an average impedance of 11.1 k ,approximately 15-fold and 3-fold lower than gold and platinum, respectively. An in vivo nerve signalrecording test was also performed using the three electrodes. The magnitude of the compound nerveaction potentials (CNAPs), the latency of the onset and the duration of the CNAPs were measured andanalyzed under various stimulus currents. The results of the CNAPs magnitude and the signal-to-noiseratio (SNR) indicated a proportional relationship to the stimulus current beyond the threshold current of0.3 mA. Our electrode has the capability to measure nerve signals less than 5 V.