High Deformability of Plasmodium vivax–Infected Red Blood Cells under Microfluidic Conditions

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High Deformability of Plasmodium vivax–Infected Red Blood Cells under Microfluidic Conditions
Title:
High Deformability of Plasmodium vivax–Infected Red Blood Cells under Microfluidic Conditions
Journal Title:
The Journal of Infectious Diseases
Keywords:
Publication Date:
17 December 2008
Citation:
Sarwo Handayani, Daniel T. Chiu, Emiliana Tjitra, Jason S. Kuo, Daniel Lampah, Enny Kenangalem, Laurent Renia, Georges Snounou, Ric N. Price, Nicholas M. Anstey, and Bruce Russell High Deformability of Plasmodium vivax-Infected Red Blood Cells under Microfluidic Conditions J Infect Dis. (2009) 199 (3): 445-450 doi:10.1086/596048
Abstract:
Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCsled to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-µm microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-µm constrictions. After this extreme deformation,67%of P. vivax-infectedRBCsrecovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria.
License type:
PublisherCopyrights
Funding Info:
Description:
Full paper can be downloaded from the Publisher's URL provided.
ISSN:
0022-1899
1537-6613
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