Cdks, cyclins and CKIs: roles beyond cell cycle regulation

Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Title:
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Other Titles:
Development
Publication Date:
08 August 2013
Citation:
Shuhui Lim and Philipp Kaldis, Cdks, cyclins and CKIs: roles beyond cell cycle regulation, Development 2013, 140:3079-3093; doi:10.1242/dev.091744
Abstract:
Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle. In addition to their well-established function in cell cycle control, it is becoming increasingly apparent that mammalian Cdks, cyclins and CKIs play indispensable roles in processes such as transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions and spermatogenesis. Even more remarkably, they can accomplish some of these tasks individually, without the need for Cdk/cyclin complex formation or kinase activity. In this Review, we discuss the latest revelations about Cdks, cyclins and CKIs with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
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Funding Info:
A*STAR
Description:
ISSN:
0950-1991
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