Translational Laboratory in Genetic Medicine

Publication date Article title Author(s)
7 Dec 2017 Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice
16 Aug 2016 Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease Marta Garcia-Miralles, Xin Hong, Liang Juin Tan, Nicholas S. Caron, Yihui Huang, Xuan Vinh To, Rachel Yanping Lin, Sonia Franciosi, Spyros Papapetropoulos, Liat Hayardeny, Michael R. Hayden, Kai-Hsiang Chuang, Mahmoud A. Pouladi
28 Apr 2016 Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease Reshmi Rajendran, Arianna Novati, Carsten Calaminus, Olaf Riess, Michael R. Hayden, Huu P. Nguyen, Roy Tang Yi Teo, Xin Hong, Libo Yu-Taeger, Yihui Huang, Liang Juin Tan, Yuanyun Xie, Xuan Vinh To, Ling Guo, Kai-Hsiang Chuang, Mahmoud A. Pouladi
11 Feb 2016 Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD Dagmar E. Ehrnhoefer, Jenny Russ, Sean-Patrick Riechers, Stefanie Butland, Yu Deng, Niels Skotte, Jean Laine, Melissa Laroche, Mahmoud A. Pouladi, Erich E. Wanker, Michael R. Hayden, Rona K. Graham
26 Jan 2016 Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease Marta Garcia-Miralles, Jolene Ooi, Costanza Ferrari Bardile, Liang Juin Tan, Maya George, Chester L. Drum, Rachel Yanping Lin, Michael R. Hayden, Mahmoud A. Pouladi
15 Nov 2014 Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease Jolene Ooi, Michael R. Hayden, Mahmoud A. Pouladi
11 Aug 2014 Preclinical models: needed in translation? A Pro/Con debate Thomas Philips, Jeffrey D. Rothstein, Mahmoud A. Pouladi