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Translational Laboratory in Genetic Medicine
Translational Laboratory in Genetic Medicine
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7 Dec 2017
Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice
16 Aug 2016
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
Marta Garcia-Miralles,
Xin Hong,
Liang Juin Tan,
Nicholas S. Caron,
Yihui Huang,
Xuan Vinh To,
Rachel Yanping Lin,
Sonia Franciosi,
Spyros Papapetropoulos,
Liat Hayardeny,
Michael R. Hayden,
Kai-Hsiang Chuang,
Mahmoud A. Pouladi
28 Apr 2016
Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
Reshmi Rajendran,
Arianna Novati,
Carsten Calaminus,
Olaf Riess,
Michael R. Hayden,
Huu P. Nguyen,
Roy Tang Yi Teo,
Xin Hong,
Libo Yu-Taeger,
Yihui Huang,
Liang Juin Tan,
Yuanyun Xie,
Xuan Vinh To,
Ling Guo,
Kai-Hsiang Chuang,
Mahmoud A. Pouladi
11 Feb 2016
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD
Dagmar E. Ehrnhoefer,
Jenny Russ,
Sean-Patrick Riechers,
Stefanie Butland,
Yu Deng,
Niels Skotte,
Jean Laine,
Melissa Laroche,
Mahmoud A. Pouladi,
Erich E. Wanker,
Michael R. Hayden,
Rona K. Graham
26 Jan 2016
Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease
Marta Garcia-Miralles,
Jolene Ooi,
Costanza Ferrari Bardile,
Liang Juin Tan,
Maya George,
Chester L. Drum,
Rachel Yanping Lin,
Michael R. Hayden,
Mahmoud A. Pouladi
15 Nov 2014
Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease
Jolene Ooi,
Michael R. Hayden,
Mahmoud A. Pouladi
11 Aug 2014
Preclinical models: needed in translation? A Pro/Con debate
Thomas Philips,
Jeffrey D. Rothstein,
Mahmoud A. Pouladi
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