p53 Laboratory

Publication date Article title Author(s)
19 Apr 2020 Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor
16 Apr 2020 Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2 Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor
18 Mar 2020 Methods and Approaches for the Solid-Phase Synthesis of Peptide Alcohols Fernando J. Ferrer-Gago, Li Quan Koh
2 Mar 2020 bioPROTACs as Versatile Modulators of Intracellular Therapeutic Targets Including Proliferating Cell Nuclear Antigen (PCNA) Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, Anthony W. Patridge
18 Dec 2019 How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor Teresa Ho, Ban Xiong Tan, David Lane
3 Dec 2019 Transmembrane signaling on a protocell: creation of receptor-enzyme chimeras for immunodetection of specific antibodies and antigens Jiulong Su, Tetsuya Kitaguchi, Yuki Ohmuro-Matsuyama, Theresa Seah, Farid J. Ghadessy, Shawn Hoon, Hiroshi Ueda
1 Dec 2019 High Intracellular Stability of the Spidroin N-terminal Domain in Spite of Abundant Amyloidogenic Segments Revealed by In-Cell Hydrogen/Deuterium Exchange Mass Spectrometry Margit Kaldmäe, Axel Leppert, Gefei Chen, Medoune Sarr, Cagla Sahin, Kerstin Nordling, Nina Kronqvist, Marta Gonzalvo-Ulla, Nicolas Fritz, Axel Abelein, Sonia Laίn, Henrik Biverstal, Hans Jornvall, David P. Lane, Anna Rising, Jan Johansson, Michael Landreh
19 Sep 2019 The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells Anja Charlotte Lundgren Mortensen, Diana Spiegelberg, Christopher John Brown, David Philip Lane, Marika Nestor
30 May 2019 Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
22 May 2019 Monitoring Flux in Signalling Pathways Through Measurements of 4EBP1-mediated eIF4F Complex Assembly Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown
29 Apr 2019 p53: Updates on Mechanisms, Biology and Therapy (II) David P. Lane, Chandra S. Verma
23 Apr 2019 p53: Updates on Mechanisms, Biology and Therapy (I) David P. Lane, Chandra S. Verma
14 Apr 2019 Understanding p53 Functions Through p53 Antibodies Kanaga Sabapathy, David P. Lane
1 Mar 2019 SHON Expression Predicts Response and Relapse Risk of Breast Cancer Patients After Anthracycline-Based Combination Chemotherapy or Tamoxifen Treatment Longxin Chen, Runlin Z. Ma, Wenming Cao, Xiaojia Wang, Yan Li, Jo K. Perry, Mohammed Aleskandarany, Christopher C. Nolan, Emad A. Rakha, Peter E. Lobie, Stephen Y. T. Chan, Ian O. Ellis, Le-Ann Hwang, David P. Lane, Andrew R. Green, Dong-Xu Liu, Tarek M. A. Abdel-Fatah, Reuben J. Broom, Jun Lu, Paul M. Moseley, Baiqu Huang, Lili Li, Suling Liu
24 Sep 2018 Ultrasensitive dynamic light scattering based nanobiosensor for rapid anticancer drug screening Xin Ting Zheng, Walter L. Goh, Peter Yeow, David P. Lane, Farid J. Ghadessy, Yen Nee Tan
30 Aug 2018 Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function S. Y. Lau, J. W. Siau, R. M. Sobota, C. I. Wang, P. Zhong, D. P. Lane, F. J. Ghadessy
19 Jul 2018 The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors Diana Spiegelberg, Anja C. Mortensen, Sara Lundsten, Christopher J. Brown, David P. Lane, Marika Nestor
16 Mar 2018 A DHODH Inhibitor Increases p53 Synthesis and Enhances Tumor Cell Killing by p53 Degradation Blockage Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Mihaela Popa, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D'Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Lain
15 Mar 2018 Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase Joana Costeira-Paulo, Joseph Gault, Gergana Popova, Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Medoune Sarr, Anders Olsson, David P. Lane, Sonia Lain, Erik G. Marklund, Michael Landreh
2 Jan 2018 Monoclonal Antibodies Against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
1 Dec 2017 Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53 Jane Vin Chan, Dawn Xin Ping Koh, Yun Liu, Thomas L. Joseph, David P. Lane, Chandra S. Verma, Yaw Sing Tan
15 Nov 2017 Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations Shilpa Yadahalli, Jianguo Li, David P. Lane, Shachi Gosavi, Chandra S. Verma
10 Nov 2017 Evidence for allosteric effects on p53 oligomerization induced by phosphorylation Petr Muller, Juliana M. Chan, Oliver Simoncik, Miroslav Fojta, David P. Lane, Ted Hupp, Borivoj Vojtesek
9 Nov 2017 A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam
27 Jun 2017 Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity Shunsheng Zheng, Xin Yu Koh, Hui Chin Goh, Siti Aishah B. Rahmat, Le-Ann Hwang, David P. Lane
13 Feb 2017 Exploiting the p53 Pathway for Therapy Chit Fang Cheok, David Philip Lane
7 Feb 2017 Anatomy of Mdm2 and Mdm4 in evolution Ban Xiong Tan, Hoe Peng Liew, Joy S. Chua, Farid J. Ghadessy, Yaw Sing Tan, David P. Lane, Cynthia R. Coffill
8 Sep 2016 Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases Hui Chin Goh, Radoslaw M. Sobota, Farid J. Ghadessy, Saurabh Nirantar
22 Apr 2016 p53 Isoforms Regulate Astrocyte-Mediated Neuroprotection and Neurodegeneration C Turnquist, I Horikawa, E Foran, EO Major, B Vojtesek, DP Lane, X Lu, BT Harris, CC Harris
15 Dec 2015 Conservative site-specific and single-copy transgenesis in human LINE-1 elements Shree Harsha Vijaya Chandra, Harshyaa Makhija, Sabrina Peter, Cho Mar Myint Wai, Jinming Li, Jindong Zhu, Zhonglu Ren, Martina Stagno D'Alcontres, Jia Wei Siau, Sharon Chee, Farid John Ghadessy, Peter Dröge
5 Aug 2015 Nutlin-3 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Cytotoxicity Yee-Lin Voon, Munirah Ahmad, Pooi-Fong Wong, Roslina Husaini, Wayne Tiong-Weng Ng, Chee-Onn Leong, David Phillip Lane, Alan Soo-Beng Khoo
5 Aug 2015 A Search for Synergy in the Binding Kinetics of Trastuzumab and Pertuzumab Whole and F(ab) to Her2 Wai-Heng Lua, Samuel Ken-En Gan, David Philip Lane, Chandra Shekhar Verma
10 Jul 2015 Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays Ban Xiong Tan, Christopher J. Brown, Fernando J. Ferrer, Tze Ying Yuen, Soo Tng Quah, Boon Hong Chan, Anna E. Jansson, Hsiang Ling Teo, Pär Nordlund, David P. Lane
19 Jun 2015 A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells Junlong Geng, Walter L. Goh, Chongjing Zhang, David P. Lane, Bin Liu, Farid J. Ghadessy, Yen Nee Tan
18 Mar 2015 Directed evolution of λ integrase activity and specificity by genetic derepression Sharon Chee, Farid J. Ghadessy, Jia Wei Siau, Harshyaa Makhija, Cho Mar Myint Wai, Shree Harsha Vijaya Chandra Chandra, Sabrina Peter, Peter Dröge
20 Feb 2015 p53 Isoform Δ113p53/Δ133p53 Promotes DNA Double-Strand Break Repair to Protect Cell From Death and Senescence in Response to DNA Damage Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David P. Lane, Jinrong Peng, Jun Chen
16 Dec 2014 Identification and Characterization of an eIF4e DNA Aptamer That Inhibits Proliferation With High Throughput Sequencing Wei Mei Guo, Kiat Whye Kong, Christopher John Brown, Soo Tng Quah, Hui Ling Yeo, Shawn Hoon, Yiqi Seow
21 Aug 2014 Autophagic degradation of the inhibitory p53 isoform D133p53a as a regulatory mechanism for p53-mediated senescence Izumi Horikawa, Kaori Fujita, Lisa M. Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris
13 Jun 2014 Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response V Marcel, K Fernandes, O Terrier, DP Lane, J-C Bourdon
29 Jan 2014 The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4 Larisa Yurlova, Maarten Derks, Andrea Buchfellner, Ian Hickson, Marc Janssen, Denise Morrison, Ian Stansfield, Christopher J. Brown, Farid J. Ghadessy, David P. Lane, Ulrich Rothbauer, Kourosh Zolghadr, Eberhard Krausz
22 Nov 2013 High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Ban Xiong Tan, Kian Hoe Khoo, Tit Meng Lim, David Lane
21 Nov 2013 On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein Karim ElSawy, Chandra S. Verma, David P. Lane, Leo Caves
17 Jan 2012 Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity A. M. Goh, C. Y. Lim, P. C. Chiam, L. Li, M. B. Mann, K. M. Mann, S. Menendez, D. P. Lane
5 Mar 2010 Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53 C F Cheok, N Kua, P Kaldis, D P Lane
1 Feb 2010 Mdm2 and p53 are highly conserved from placozoans to man David P. Lane, Chit Fang Cheok, Christopher Brown, Arumugam Madhumalar, Farid J. Ghadessy, Chandra Verma
21 Aug 2008 The Trichoplax genome and the nature of placozoans Mansi Srivastava, Emina Begovic, Jarrod Chapman, Nicholas H. Putnam, Uffe Hellsten, Takeshi Kawashima, Alan Kuo, Therese Mitros, Asaf Salamov, Meredith L. Carpenter, Ana Y. Signorovitch, Maria A. Moreno, Kai Kamm, Jane Grimwood, Jeremy Schmutz, Harris Shapiro, Igor V. Grigoriev, Leo W. Buss, Bernd Schierwater, Stephen L. Dellaporta, Daniel S. Rokhsar